Hana Tomoi, Sharon Janet Bruce Hanley, Heidi Larson, and Ken Masuda
Determinants of Human Papillomavirus Vaccination Decision-Making in Japan: A Narrative Literature Review Exploring Contextual, Social, and Adolescent-Specific Influences
Abstract
Human papillomavirus (HPV) vaccination coverage in Japan was initially over 70%, but it dramatically declined following 2013 media reports of adverse events, leading to public fear and suspension of proactive government recommendations. Despite the resumption of the recommendations in 2022, public trust remains low, with 40.9% of girls and mothers still undecided about HPV vaccination. This review synthesises evidence on the determinants of HPV vaccination decision-making among caregivers and adolescent girls in Japan and identifies research gaps to guide future research. 【Methods】 A literature search was conducted using three key topics: HPV vaccination, willingness, and adolescent girls or caregivers. Studies were selected, focusing on research that examined influences on HPV vaccination decision-making in Japan. Determinants were categorized using the World Health Organization (WHO) Strategic Advisory Group of Experts on Immunisation vaccine hesitancy matrix. 【Results】 This review identified a wide range of determinants influencing HPV vaccination decision-making, including contextual, individual and group, and vaccine-specific factors. Contextual influences, such as government recommendations and negative media coverage, play a significant role in shaping public attitudes. Individual and group factors, including parental knowledge, healthcare provider recommendations, and peer norms, are also critical. Vaccine-specific issues, such as concerns about safety, cultural barriers, and inadequate sex education, further complicate decision-making. Three key gaps were also identified: (1) insufficient exploration of contextual influences, including Japan’s unique socio-cultural landscape and historical mistrust; (2) limited understanding of how adolescents navigate social group influences and integrate conflicting information into their decisions; and (3) a lack of focus on the specific perceptions of adolescent girls. 【Conclusions】 Addressing these gaps requires interdisciplinary research that incorporates socio-cultural, behavioural and systemic perspectives. Further research and tailored interventions are essential to rebuild public trust and increase HPV vaccine uptake in Japan.